The collection consists of interviews with Georgia O'Keeffe's surviving relatives, colleagues, friends, and employees as well as supporting project documentation. The bulk of the materials date from 2000 to 2003 and include audiocassette recordings, typed transcripts, photographs, and research and project records.

June O'Keeffe Sebring (b. 1928) is the niece of O'Keeffe and daughter of Alexius Wyckoff O'Keeffe and Elizabeth (Betty) Jones. She was a member of the board of directors of The Georgia O'Keeffe Foundation. Sebring visited O'Keeffe throughout the course of her lifetime. Sebring was interviewed by Sarah Burt.