The collection consists of interviews with Georgia O'Keeffe's surviving relatives, colleagues, friends, and employees as well as supporting project documentation. The bulk of the materials date from 2000 to 2003 and include audiocassette recordings, typed transcripts, photographs, and research and project records.

Louis Rosen (1918-2009) was a physicist at Los Alamos Laboratories. He and his wife Mary (Terry) Rosen (1918-2004), an artist in her own right, became friends with O'Keeffe after being introduced by Elizabeth Allred, O'Keeffe's neighbor. Rosen was interviewed by Sarah Burt.