In 1999, The Georgia O'Keeffe Foundation and the Georgia O'Keeffe Museum began working together on the Georgia O'Keeffe Oral History Project with the goal of recording and transcribing interviews with Georgia O'Keeffe's surviving relatives, colleagues, friends, and employees.

The co-directors of the project, Agapita Judy Lopez (Director, The Georgia O'Keeffe Foundation) and Barbara Buhler Lynes (Curator and Emily Fisher Landau Director of the Research Center, Georgia O'Keeffe Museum) developed a list of individuals to be interviewed by Sarah L. Burt and Jane Cook. The bulk of the interviews were conducted from 2000 to 2003.

The interviews cover a range of topics with special attention to the interviewees' interactions with O'Keeffe and her contributions to the art world and her community.

Most of the interviews were recorded on audiocassettes and were later transcribed by the interviewer. Transcripts and audio recordings have been digitized by the Museum.