The bulk of the collection consists of handwritten letters from Georgia O'Keeffe to her sister, Anita O'Keeffe Young, dating from the 1940s to the 1970s. The letters largely relate to personal matters, daily activities, and the management of O'Keeffe's paintings. There is some correspondence between O'Keeffe and Robert R. Young, Anita O'Keeffe Young's husband, and his assistant Florence McCormick, related to financial matters. Additionally, there are five small photographs and one article clipping.

Accruals for this collection include additional correspondence, primarily of a business nature relating to Georgia O'Keeffe paintings in the possession of Anita Young and her estate. Also included are over 40 family photographs, over 100 photographs of O'Keeffe paintings, and some images of Ireland, as well as ephemera related to Isabel Dunham Wyckoff Totto (Georgia O'Keeffe's grandmother) and legal documents concerning O'Keeffe's lawsuit with Doris Bry and the settlement of O'Keeffe's estate.