The collection includes 232 letters, primarily from Georgia O'Keeffe (1887-1986) to her husband Alfred Stieglitz (1864-1946), dating from 1933 to 1944. Between 1915 and 1946 O'Keeffe and Stieglitz exchanged over 5,000 letters; this is only a small sample of the rich correspondence between the two. The letters are personal in nature and discuss the lives and careers of O'Keeffe and Stieglitz. Some of the letters are "notes" left by O'Keeffe to be found by Stieglitz while she was in New Mexico. On these notes Stieglitz inscribes where and when he found them; for example, "Found in my slippers / Apr 28/43 / Georgia had left for New Mexico." A few of the letters include enclosures such as feathers, tissue paper, dried flowers, or pine needles. In a letter from 1944, O'Keeffe encloses two photographs of her Black Place paintings and one photograph of a pelvis bone painting.

Also included are three letters from Maria Chabot, one from "Ann", and one from Ansel Adams to Stieglitz.